The behavioural and neuroprotective outcomes when 670nm and 810nm near infrared light are applied together in MPTP-treated mice.
Identifieur interne : 000236 ( Main/Exploration ); précédent : 000235; suivant : 000237The behavioural and neuroprotective outcomes when 670nm and 810nm near infrared light are applied together in MPTP-treated mice.
Auteurs : Florian Reinhart [France] ; Nabil El Massri [Australie] ; Napoleon Torres [France] ; Claude Chabrol [France] ; Jenny Molet [France] ; Daniel M. Johnstone [Australie] ; Jonathan Stone [Australie] ; Alim-Louis Benabid [France] ; John Mitrofanis [Australie] ; Cécile Moro [France]Source :
- Neuroscience research [ 1872-8111 ] ; 2017.
Abstract
We have shown previously that when applied separately, 670nm and 810nm near infrared light (NIr) reduces behavioural deficits and offers neuroprotection in a MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) mouse model of Parkinson's disease. Here, we explored the beneficial outcomes when these NIr wavelengths were applied both together, either concurrently (at the same time) or sequentially (one after the other). Mice received MPTP injections (total of 50mg/kg) and had extracranial application of 670nm and/or 810nm NIr. Behavioural activity was tested with an open-field test and brains were processed for tyrosine hydroxylase immunohistochemistry and stereology. Our results showed that when 670nm and 810nm NIr were applied both together and sequentially, there was a greater overall beneficial outcome - increased locomotor activity and number of tyrosine hydroxylase immunoreactive cells in the substantia nigra pars compacta - than when they were applied either separately, or in particular, both together and concurrently. In summary, our findings have important implications for future use of NIr therapy in humans, that there are some combinations of wavelengths that provide more beneficial outcome than others.
DOI: 10.1016/j.neures.2016.11.006
PubMed: 27871905
Affiliations:
- Australie, France
- Auvergne-Rhône-Alpes, Nouvelle-Galles du Sud, Rhône-Alpes
- Sydney
- Université de Sydney
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Johnstone</name><affiliation wicri:level="4"><nlm:affiliation>Dept of Physiology F13, University of Sydney, 2006, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Dept of Physiology F13, University of Sydney, 2006</wicri:regionArea><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Stone, Jonathan" sort="Stone, Jonathan" uniqKey="Stone J" first="Jonathan" last="Stone">Jonathan Stone</name><affiliation wicri:level="4"><nlm:affiliation>Dept of Physiology F13, University of Sydney, 2006, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Dept of Physiology F13, University of Sydney, 2006</wicri:regionArea><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Benabid, Alim Louis" sort="Benabid, Alim Louis" uniqKey="Benabid A" first="Alim-Louis" last="Benabid">Alim-Louis Benabid</name><affiliation wicri:level="1"><nlm:affiliation>CLINATEC, EJ Safra Centre, CEA, LETI, University of Grenoble Alpes, F38000, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CLINATEC, EJ Safra Centre, CEA, LETI, University of Grenoble Alpes, F38000</wicri:regionArea><wicri:noRegion>38000</wicri:noRegion><wicri:noRegion>38000</wicri:noRegion></affiliation></author><author><name sortKey="Mitrofanis, John" sort="Mitrofanis, John" uniqKey="Mitrofanis J" first="John" last="Mitrofanis">John Mitrofanis</name><affiliation wicri:level="4"><nlm:affiliation>Dept of Anatomy F13, University of Sydney, 2006, Australia. Electronic address: john.mitrofanis@sydney.edu.au.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Dept of Anatomy F13, University of Sydney, 2006</wicri:regionArea><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Moro, Cecile" sort="Moro, Cecile" uniqKey="Moro C" first="Cécile" last="Moro">Cécile Moro</name><affiliation wicri:level="1"><nlm:affiliation>CLINATEC, EJ Safra Centre, CEA, LETI, University of Grenoble Alpes, F38000, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CLINATEC, EJ Safra Centre, CEA, LETI, University of Grenoble Alpes, F38000</wicri:regionArea><wicri:noRegion>38000</wicri:noRegion><wicri:noRegion>38000</wicri:noRegion></affiliation></author></analytic><series><title level="j">Neuroscience research</title><idno type="eISSN">1872-8111</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We have shown previously that when applied separately, 670nm and 810nm near infrared light (NIr) reduces behavioural deficits and offers neuroprotection in a MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) mouse model of Parkinson's disease. Here, we explored the beneficial outcomes when these NIr wavelengths were applied both together, either concurrently (at the same time) or sequentially (one after the other). Mice received MPTP injections (total of 50mg/kg) and had extracranial application of 670nm and/or 810nm NIr. Behavioural activity was tested with an open-field test and brains were processed for tyrosine hydroxylase immunohistochemistry and stereology. Our results showed that when 670nm and 810nm NIr were applied both together and sequentially, there was a greater overall beneficial outcome - increased locomotor activity and number of tyrosine hydroxylase immunoreactive cells in the substantia nigra pars compacta - than when they were applied either separately, or in particular, both together and concurrently. In summary, our findings have important implications for future use of NIr therapy in humans, that there are some combinations of wavelengths that provide more beneficial outcome than others.</div></front></TEI><affiliations><list><country><li>Australie</li><li>France</li></country><region><li>Auvergne-Rhône-Alpes</li><li>Nouvelle-Galles du Sud</li><li>Rhône-Alpes</li></region><settlement><li>Sydney</li></settlement><orgName><li>Université de Sydney</li></orgName></list><tree><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Reinhart, Florian" sort="Reinhart, Florian" uniqKey="Reinhart F" first="Florian" last="Reinhart">Florian Reinhart</name></region><name sortKey="Benabid, Alim Louis" sort="Benabid, Alim Louis" uniqKey="Benabid A" first="Alim-Louis" last="Benabid">Alim-Louis Benabid</name><name sortKey="Chabrol, Claude" sort="Chabrol, Claude" uniqKey="Chabrol C" first="Claude" last="Chabrol">Claude Chabrol</name><name sortKey="Molet, Jenny" sort="Molet, Jenny" uniqKey="Molet J" first="Jenny" last="Molet">Jenny Molet</name><name sortKey="Moro, Cecile" sort="Moro, Cecile" uniqKey="Moro C" first="Cécile" last="Moro">Cécile Moro</name><name sortKey="Torres, Napoleon" sort="Torres, Napoleon" uniqKey="Torres N" first="Napoleon" last="Torres">Napoleon Torres</name></country><country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Massri, Nabil El" sort="Massri, Nabil El" uniqKey="Massri N" first="Nabil El" last="Massri">Nabil El Massri</name></region><name sortKey="Johnstone, Daniel M" sort="Johnstone, Daniel M" uniqKey="Johnstone D" first="Daniel M" last="Johnstone">Daniel M. Johnstone</name><name sortKey="Mitrofanis, John" sort="Mitrofanis, John" uniqKey="Mitrofanis J" first="John" last="Mitrofanis">John Mitrofanis</name><name sortKey="Stone, Jonathan" sort="Stone, Jonathan" uniqKey="Stone J" first="Jonathan" last="Stone">Jonathan Stone</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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